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Angiotensin II Stress Test. Renin Kinetics During Treatment of Vasoplegic Shock With Angiotensin II.

Recruitingn/aAges 18 Years - anyAllUniversity Medical Centre Maribor
NCT06539234 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Shock is a life-threatening condition which can cause multiple organ failure and even death. One characteristic of shock is low blood pressure which is managed with drugs called vasopressors. Most frequently used vasopressors are noradrenaline, vasopressin and recently also angiotensin II. Angiotensin II is present in the body and has a physiological role in maintaining blood pressure in healthy persons. Renin is an enzyme and a key factor in angiotensin II production in the body. In patients with shock, there is a lack of angiotensin II and an excess of renin in the body. Due to the literature renin has the potential to be a marker of severity of shock. Synthetic angiotensin II is used in patients with shock in whom we cannot normalize the blood pressure with noradrenaline and vasopressin. Regarding scientific data, the use of synthetic angiotensin II reduces the dose of noradrenaline a

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📋 Eligibility rules (as published)
Inclusion Criteria: * patients with distributive shock lasting \< 72 hours * a goal mean arterial pressure (65-85 mmHg) not achieved despite optimal fluid resuscitation (30 ml/kg cristalloid) and an infusion of at least noradrenaline 0.3 mcg/kg/min and vasopressin 0.03 IE/min * the patient did not get angiotensin II before * predicted survival is \>24h * no limitations for active treatment Exclusion Criteria: * burns \>20% body area * acute coronary syndrome * bronchospasm * liver disease (MELD ≥30) * severe acute bleeding (need for 4 or more units of concentrated erythrocyte) * acute mesenteric ischemia * aortic dissection * leucopenia \<1000/mm3 * pregnancy * Raynaud disease, systemic sclerosis, vasospastic disease * active venous or arterial thromboembolic disease * the need for daily dose of hydrocortisone 500 mg or more * ECMO * cardiac index \<l/min/m2 (defined by echocardiography or invasive methods) * central venous oxygen saturation (SCVO2) \>70%
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What it tests

  • Not listed
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Where

2 sites
Medical ICU, University Medical Centre Maribor
Maribor, Slovenia
Surgical ICU, University Medical Centre Maribor
Maribor, Slovenia
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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