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Pharmacokinetics Vancomycin CVVHDF with OXiris Membrane

RecruitingNAAges 18 Years - anyAllMahidol University
NCT06543940 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study is a general pharmacokinetic investigation of vancomycin in patients receiving continuous veno-venous hemodiafiltration (CRRT) with the oXiris membrane. This membrane offers the added benefit of absorbing inflammatory cytokines. In vitro studies show that vancomycin is reduced by around 20 percent in patients using the AN69ST membrane, which is part of the oXiris membrane's structure. However, there is currently a lack of in vivo studies demonstrating the impact of the oXiris membrane on vancomycin levels. Therefore, the hypothesis of this study is that vancomycin is also reduced by absorption in the oXiris membrane. This study measures the levels of vancomycin in these patients to determine the pharmacokinetic parameters.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients aged more than 18 years. * Admitted to the intensive care unit of Ramathibodi Hospital. * Under continuous renal replacement therapy (CRRT) with CVVHDF using oXiris filter. * Received vancomycin at least once after starting CRRT with CVVHDF using oXiris filter. * who have signed the informed consent document. Exclusion Criteria: * Patients with a history of vancomycin allergy. * Patients expected to die within 24 hours after inclusion in study. * Patients with circuit clotting occurring more than 2 hours during the blood draw period. * Patients treated with extracorporeal membrane oxygenation (ECMO). * Patients with a history of kidney transplantation. * Pregnant or breastfeeding women. * Patients who have decided to receive palliative care. * Patients on hemodialysis or peritoneal dialysis.
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What it tests

  • Vancomycin
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Where

1 site
Facullty of Pharmacy Mahidol University
Bangkok, Thailand
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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