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Investigating Different Frequencies of Transcranial Electrical Stimulations in Dementia Population

RecruitingNAAges 50 Years - 95 YearsAllUniversity of Manitoba
NCT06547021 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Dementia is a prevalent condition with no known cure. It affects not only the person with dementia but also the family. This study will investigate the effects of applying different transcranial electrical stimulation (tES) waveforms to find the optimal stimulation when paired with cognitive exercise on older adults with dementia. It is a placebo-controlled double-blind study with statistical rigor. In addition, the investigators will investigate technological methods to monitor changes due to the intervention. These include functional near infrared spectroscopy (fNIRS), electroencephalography (EEG), electrovestibulography (EVestG), and balance measurements using accelerometers. fNIRS measures oxygenated and deoxygenated blood flow to the brain and it may help to understand neuronal changes due to intervention. EEG measures the electrical activity of the brain via electrodes placed on th

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📋 Eligibility rules (as published)
Inclusion Criteria: * MoCA score between 5 and 24 * Between the age of 50 and 95 years old Exclusion Criteria: * Being diagnosed with Parkinson's, Parkinsonian dementia, Huntington disease, speech significant aphasia and intellectual disability, major depression/anxiety, bipolar disorder, schizophrenia or any other major mood disorder. * Having a History of epileptic seizures or epilepsy * Inability to adequately communicate in English * Impaired vision or hearing severe enough to impair performance in cognitive tests * Current substance abuse disorder * Currently participating in another therapeutic study for dementia * Change to medication for Alzheimer's disease, dementia, or depression
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What it tests

  • Transcranial Direct Current Stimulation (tDCS)
  • Gamma Transcranial Alternating Current Stimulation (tACS)
  • Theta Transcranial Alternating Current Stimulation (tACS)
  • Sham
  • Gamma Transcranial Alternating Current Stimulation (tACS)-Precuneus
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Where

1 site
Riverview Health Centre
Winnipeg, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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