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Use of Vasopressin in Patients at High Risk of Acute Kidney Injury Admitted to the ICU

RecruitingPhase 2Ages 18 Years - anyAllHospital do Coracao
NCT06547892 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Renal dysfunction is a frequent complication in patients admitted to intensive care units (ICUs), associated with high morbidity and mortality. Current therapeutic options to prevent this condition are limited and lack robust scientific evidence. This pilot study consists of a multicenter, blinded, randomized clinical trial, unprecedented in the literature to date, aiming to fill this knowledge gap and offer new therapeutic perspectives to improve renal outcomes in critically ill patients admitted to the ICU.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adult patients (≥18 years old); * Admitted to intensive care units; * Predicted risk of acute kidney injury calculated based on clinical and laboratory data at ICU admission and is considered eligible if the value in the calculator is equal or greater than 5 points; Exclusion Criteria: * Time since admission to the ICU greater than 24 hours; * Use of vasopressors at the time of inclusion; * MAP \>90 mmHg; * Hyponatremia (\<130 mmol/L); * Severe TBI with Glasgow Coma Scale \< 8; * Elective surgeries; * Dialysis chronic kidney disease or acute kidney injury who received renal replacement therapy upon admission or are expected to receive renal replacement therapy within the next 24 hours; * Suspected or confirmed acute mesenteric ischemia; * Prospect of death in less than 24 hours; * Medical team not committed to full investment at the time of inclusion; * Prior inclusion in the study; * Pregnancy.
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What it tests

  • Vasopressin
  • 0,9% saline solution
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Where

1 site
Matheus Liguori Feliciano da Silva
São Paulo, Brazil
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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