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Evaluation of Nasal Non Invasive Ventilation in Management of Neonates With Respiratory Distress Using Lung Ultrasound

RecruitingNAAges 1 Hour - 24 HoursAllAlexandria University
NCT06550219 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study aims to evaluate the effect of non-invasive ventilation (nIPPV) , (nCPAP), and nasal high flow cannula (NHFC) as a primary mode of ventilation in preterm neonates \<37 gestational week with moderate to severe RD using LUS as regard: I. Primary outcomes: Duration of non-Invasive ventilation. II. Secondary outcomes: Evaluation LUS over the 1 st 7 days of life or weaning from ventilation. Need for intubation and invasive ventilation. Duration of respiratory support. Need for surfactant. Oxygen saturation index and oxygen index. Broncho-pulmonary dysplasia; grade. Duration of hospital stay

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📋 Eligibility rules (as published)
Inclusion Criteria: Preterm \<37 wk. gestational age admitted to the NICU with spontaneous breathing and clinical manifestations of RD (tachypnea, nasal flaring, intercostal and subcostal retraction and or grunting). Exclusion Criteria: 1. Obvious major congenital abnormalities. 2. Any of the baby intubated for resuscitation or for other reasons. 3. Neonates need invasive mechanical ventilation. 4. Pulmonary hemorrhage. 5. Severe cardiovascular instability. 6. Cardiopulmonary arrest needing prolonged resuscitation. 7. Birth asphyxia (one-minute Apgar score ≤ 3). 8. Major cardiac diseases (not including patent ductus arteriosus).
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What it tests

  • Nasal humidified heated high flow cannula (NHHHC)
  • Nasal intermittent positive pressure ventilation (NIPPV)
  • Nasal continuous positive airway pressure NCPAP
  • lung ultrasound
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Where

1 site
Alexandria university, Elshattbi hospital
Alexandria, Egypt
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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