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Spastic Paraplegia - Centers of Excellence Research Network

Recruitingn/aAges any - anyAllBoston Children's Hospital
NCT06553976 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The Spastic Paraplegia - Centers of Excellence Research Network (SP-CERN) is a collaborative research consortium dedicated to advancing the understanding, diagnosis, and treatment of hereditary spastic paraplegia (HSP) and primary lateral sclerosis (PLS). Aims of the consortium are to a) perform natural history studies of HSP subtypes, b) discover and validate biomarkers and clinician- and patient-reported outcome measures, c) uncover HSP's molecular pathophysiology and develop rational therapeutic targets, and d) perform sufficiently powered clinical trials. The current pilot study is aimed at enrolling 100 individuals with hereditary spastic paraplegia type 4 (SPG4) or hereditary spastic paraplegia type 5A (SPG5A).

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📋 Eligibility rules (as published)
Inclusion Criteria: * Male or female patients of all ages with a clinical and molecular diagnosis of hereditary spastic paraplegia type 4 (SPG4, SPAST) or hereditary spastic paraplegia type 5A (SPG5A, CYP7B1). Exclusion Criteria: * Not having such a diagnosis and/or not being related to such individual.
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What it tests

  • Not listed
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Where

11 sites
University of Miami Miller School of Medicine
Miami, United States
University of Iowa Carver College of Medicine
Iowa City, United States
Boston Children's Hospital
Boston, United States
Massachusetts General Hospital
Boston, United States
University of Michigan School of Medicine
Ann Arbor, United States
Columbia University - Irving Medical Center
New York, United States
Cincinnati Children's Hospital Medical Center
Cincinnati, United States
Scottish Rite for Children
Dallas, United States

…and 3 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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