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Utilising AI Analysis of Sounds To prEdict heaRt failurE decOmpensation

Recruitingn/aAges 18 Years - anyAllCambridge University Hospitals NHS Foundation Tru…
NCT06555757 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Heart failure impacts more than 2% of people in the UK (United Kingdom) and leads to about 5% of emergency hospital visits. Patients might have slowly worsening symptoms or suddenly face acute decompensated heart failure (ADHF), marked by intense difficulty in breathing due to fast-developing lung congestion. This is a serious emergency requiring in-hospital treatment and monitoring. Once stable, patients usually have a phase where symptoms remain constant. But as time goes on, those with heart failure often face more frequent and prolonged episodes of ADHF. Fluid build-up (pulmonary congestion) in the lungs is a key issue in heart failure, and catching it early helps avoid unexpected hospital stays. Spotting these early signs outside the hospital can be tough, as symptoms aren't always clear. Study investigators are working on a new, non-invasive way to identify these early signs using

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📋 Eligibility rules (as published)
Inclusion Criteria: * Male or Female, aged 18 years or above. * Diagnosed with chronic stable heart failure NYHA Class 3 or 4 (either during most recent cardiology/heart failure clinic visit, or ADHF during recent/current hospitalization). * Participant is willing and able to give informed consent for participation in the study. * Participant has a smartphone device and can download a purposely designed mobile application on their phone (with guidance from the study investigators) or is willing to have sound recordings via a smartphone device loaned for the purpose of the study. Exclusion Criteria: * Unable to provide consent * Patients requiring continuous oxygen therapy at flow rates that cannot be provided through nasal cannula * Patients with currently known pneumonia * Patients with known significant pulmonary disease including asthma, COPD, pulmonary fibrosis/interstitial lung disease, pulmonary hemorrhage. * Patients with current Pulmonary embolus * Patients with other intercurrent acute symptomatic illness (e.g., viral/bacterial infection) at time of recording * Patients requiring continuous oxygen therapy at flow rates that cannot be provided through nasal cannula * Patients with tracheostomy or who have undergone a surgical procedure to the head/neck/larynx which would affect the normal functioning of the vocal cords. * Aphasic * Patients excluded at PI discretion
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What it tests

  • Height, weight, and BMI
  • Medical history
  • Physical examination
  • Venous blood samples
  • Resting vital signs
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Where

1 site
Cambridge University Hospitals NHS Foundation Trust
Cambridge, United Kingdom
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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