🌐 EnglishEN

AI Cure is a research tool showing open data. Not medical advice. Discuss with your doctor. Terms

← Trials
🧪

IV vs Epidural Opioids + Epidural Local Anesthetic for Laparotomy Analgesia

RecruitingPhase 2, Phase 3Ages 18 Years - 85 YearsAllUniversity of Iowa
NCT06559969 on ClinicalTrials.gov ↗
💬

In plain words

What the trial is, and whether it could suit you

The purpose of this research study is to determine if the two common ways of administering additional opioids (morphine like substance, narcotic) with an epidural, either mixed in the epidural solution or given separately through the intravenous, are equally effective in controlling post-operative pain

Sign in to get the eligibility rules as simple questions to take to your doctor.

Sign in
📋 Eligibility rules (as published)
Inclusion Criteria: 1. Age including and between 18 to 85 years old 2. Planned open abdominal procedure with an incision that is or includes above the umbilicus, where epidural would normally be offered and epidural would be maintained for an average of 4 to 5 days 3. Patient has consented for an epidural 4. Patient is able to converse in English 5. Patient is able to use a patient controlled pump Exclusion Criteria: 1. Has a known contraindication for an epidural 2. Known mental or cognitive disability 3. History of chronic opioid use or substance abuse disorder 4. Pre-operative use of opioids 5. History of chronic pain 6. Routine use of marijuana 7. Incarcerated 8. Unable to converse in English 9. Planned to remain intubated post-operatively 10. Need for post-operative use of anticoagulant regiment that would be contraindicated with an indwelling epidural catheter 11. End stage renal disease or dialysis 12. Hepatic disease that affects metabolism of drugs 13. Known contraindication to any of the study drugs 14. Known pregnancy or positive pre-operative pregnancy test 15. Known neurological condition that may affect motor or sensory systems
💊

What it tests

  • Intravenous administered opioid
  • Epidural administered opioid
📍

Where

1 site
University of Iowa Health Care
Iowa City, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
🛡️

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it — not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use · Privacy