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A Cohort Study of Hereditary Ovarian Cancer Risk Prediction Models and Pathogenesis Exploration

Recruitingn/aAges 18 Years - anyFemalePeking University Third Hospital
NCT06564428 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The aim of this project is to establish a bidirectional multicenter cohort of hereditary ovarian cancer and to describe the clinicopathologic features of hereditary ovarian cancer patients in our country. The risk prediction model of ovarian cancer for Chinese was established by following-up analysis of clinical and pathological information, genetic test results and detailed family history, to predict the risk of cancer in first-degree relatives of carriers of pathogenic/suspected pathogenic mutations, and to guide the intervention management of high-risk population of cancer. The study will identify novel tumor-causing mutations/predisposing genes by gene sequencing in a special family with hereditary tumor.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Epithelial ovarian cancer * ≥18 years * The pathological diagnosis was clear * The genetic test showed germ line pathogenic/suspected pathogenic mutations (for mutation interpretation, refer to the American ACMG Classification Standards and Guidelines for Genetic Variation) Exclusion Criteria: * Non-epithelial ovarian cancer was confirmed by pathology * No genetic test has been performed
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What it tests

  • Suspective gene mutations and family history
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Where

1 site
Peking University Third Hospital
Beijing, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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