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Multiple Sclerosis Treatment With Autologous Hematopoietic Stem Cell Transplantation in the Netherlands

Recruitingn/aAges 18 Years - 65 YearsAllAmsterdam UMC, location VUmc
NCT06567197 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this observational study is to study the long-term effects of autologous hematopoietic stem cell transplantation (aHSCT) in people with highly active relapsing-remitting multiple sclerosis. The study will evaluate the following items: 1. Disease activity 2. Safety and tolerability of aHSCT 3. Changes in the immune system Participants will be subjected to frequent visits for five years after treatment with aHSCT. During these visits, clinical testing, evaluation by questionnaires, MRI scans and blood sampling will be performed.

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📋 Eligibility rules (as published)
Inclusion Criteria: * All patients approved for treatment with aHSCT in the Netherlands in accordance with the Dutch criteria for aHSCT treatment for RRMS Exclusion Criteria: * Contra-indications for treatment with aHSCT such as known hypersensitivity to the medication used for aHSCT * Clinically relevant comorbidities preventing safe use of medication used for aHSCT * Severe clinical depression * Active addiction to drugs or alcohol * Active infections such as but not limited to tuberculosis, cytomegalovirus, Epstein-Barr virus, herpes simplex, varicella zoster, viral hepatitis, toxoplasmosis, HIV or syphilis. * Active malignancy or history of malignancy with the exception of local basal cell carcinoma or carcinoma in situ of the cervix
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What it tests

  • Not listed
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Where

2 sites
Amsterdam UMC
Amsterdam, Netherlands
St. Antonius Hospital
Nieuwegein, Netherlands
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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