Superselective Adrenal Arterial Embolization for Refractory Hypertension: A Proof-of-Concept Study

Inclusion Criteria: * Age \> 18 years, no gender restrictions; * Primary refractory hypertension: Taking three antihypertensive drugs, including a - diuretic, with an average office systolic blood pressure ≥150 mmHg measured three times; * Duration of hypertension greater than 6 months; * Standing plasma aldosterone and renin activity not below the lower limit of the unit's reference range; * Signed informed consent form. Exclusion Criteria: * Morning cortisol level \< 4.3 µg/dL; estimated glomerular filtration rate (eGFR) \< 45 mL/min/1.73 m²; serum potassium level \> 5.5 mmol/L; * Type 1 diabetes, uncontrolled hyperthyroidism, malignant arrhythmias, malignant tumors, decompensated heart failure, severe liver dysfunction, severe hematological diseases, severe obstructive sleep apnea syndrome, history of myocardial infarction, syncope, cerebral hemorrhage, or cerebral infarction within the past 3 months; * Pregnant women or those planning to conceive within the next year; * Presence of other severe organic diseases that would make the patient unable to tolerate superselective adrenal arterial embolization; * Adrenal mass with a diameter exceeding 2 cm; * Severe allergy to contrast agents; * Patients enrolled or planning to participate in other clinical studies that could impact the results of this study.