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Evaluation of Dentin Graft and I-PRF With and Without Vitamin C for Post-extraction Socket Preservation

RecruitingNAAges 18 Years - 65 YearsAllCairo University
NCT06569264 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The aim of the study is to evaluate radiographic ridge width change following autogenous demineralized dentin graft (ADDG) and i-PRF addition with and without vitamin C (AA) for post extraction socket preservation. The main question is: In patient with non-restorable teeth, does adding vitamin C to dentin graft and i-PRF affect the radiographic ridge width of post extraction sockets? Intervention group: Alveolar ridge preservation using vitamin C (AA) with autogenous demineralized dentin graft combined with i-PRF. Adding vitamin C to dentin graft and i-PRF might aid in reducing the dimensional changes, since it increases osteoblast proliferation and viability during socket preservation. Layers of osteoblast cell morphology can be seen at day 11 with the presence of 25mM of vitamin C. By adding vitamin C to i-PRF we can add the advantages of improving soft tissue quality as well. Co

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📋 Eligibility rules (as published)
Inclusion Criteria: Inclusion criteria: * ≥ 18 years of age. * Single extraction of non-molar teeth with periodontally healthy adjacent teeth. * Non-contributory medial history. * Non- restorable teeth indicated for extraction. * Requiring alveolar preservation after tooth extraction prior to placement of dental implant. * Participants that are eligible for immediate implantation, yet having factors that are hindering these patients from immediate placement of an implant at the time of extraction (ex: Financial related factors - psychological psychological factors - time related factors). * Cooperative patients who are willing to commit for 3 months follow up. Exclusion Criteria: * Pregnant female. * Acute infection at extraction site. * Systemic conditions affecting healing (e.g., diabetes, medications as bisphosphonates...) * A participant who had radiotherapy or chemotherapy. * Psychiatric patient, or with a learning disability, or unable to give consent.
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What it tests

  • Alveolar ridge preservation using autogenous demineralized dentin graft and i-PRF
  • Alveolar ridge preservation using vitamin C with dentin graft and i-PRF
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Where

1 site
Faculty of Dentistry, Cairo University
Cairo, Egypt
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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