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The Effect of Dexmedetomidine on the Renal Functions in Septic Critically Ill Patients

RecruitingPhase 4Ages 18 Years - 90 YearsAllCairo University
NCT06570187 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This clinical trial aims to evaluate the effect of dexmedetomidine in Sepsis-Associated Acute Kidney Injury in critically ill patients by answering the following questions: 1. What is dexmedetomidine's effect on kidney functions? 2. What is the safety and efficacy of dexmedetomidine in Sepsis-Associated Acute Kidney Injury? The investigator will compare dexmedetomidine to the standard sedative. The Participant will take either dexmedetomidine or the standard sedative during their hospitalization, with follow-up of the following: 1. Vital signs including blood pressure, body temperature, respiratory rate, heart rate, and oxygen saturation. 2. Laboratory data including kidney function tests, electrolytes, complete blood count, and liver function tests. 3. An electrocardiogram will be followed to check the heart's electrical activity. 4. The level of alertness or agitation to avoid over

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age \>21 years old * Patients with sepsis who develop AKI within 48 hours during ICU stay * Need for sedation due to the need for mechanical ventilation (MV) (both invasive and non- invasive) within 48 hours of AKI Exclusion Criteria: * Contraindications to dexmedetomidine including any of the following: severe bradycardia (heart rate (HR) \< 50 beats/min), sick sinus syndrome or second-to-third degree atrioventricular block unless a pacemaker is inserted * Acute myocardial ischemia * Mean arterial blood pressure \< 50 mmHg despite adequate resuscitation and vasopressor therapy at the time of enrollment * Pregnancy or lactation * Duration of dexmedetomidine infusion \< 24 hours * Severe valvular heart disease * Active seizures during this ICU admission requiring benzodiazepines * Proven or suspected traumatic brain injury, intracranial hemorrhage, stroke, or spinal cord injury
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What it tests

  • Dexmedetomidine
  • Propofol
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Where

1 site
Cairo University
Cairo, Egypt
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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