Efficacy and Safety of Remimazolam Besylate for Sedation in Post-Non-Cardiac Surgery Patients Requiring Mechanical Ventilation

Inclusion Criteria: * Aged between 18 and 64 years * Scheduled to undergo elective non-cardiac surgery * Planned for general anesthesia * With or without combined regional nerve blockade * Admitted to the ICU with endotracheal intubation post-surgery * With an anticipated duration of postoperative mechanical ventilation greater than 24 hours * Clinically requiring light sedation( target RASS score 0 to -2) Exclusion Criteria: * Undergoing intracranial surgery, or having a history of severe neurological or spinal cord diseases * Pre-existing history of schizophrenia, epilepsy, or Parkinson's disease * Inability to communicate preoperatively due to coma, severe dementia, or language barriers * Preoperative .cardiac insufficiency or severe cardiac arrhythmias * Severe hepatic impariment( Child-Pugh class C) * Severe renal impariment * Preoperative( within 24 hours prior to surgery) or intraoperative administration of dexmedetomidine or remimazolam * Pregnancy or lactation * Participation in any clinical trial involving investigational drugs within 30 days prior to enrollment * Any other conditions deemed by the investigators to render the patient unsuitable for study participation * Refusal to provide written informed consent