💬In plain words
What the trial is, and whether it could suit you
Individuals with tic disorders have lower quality of life, sensory and movement difficulties, and poorer mental, social, and physical health compared to the general population. Current clinical care for individuals with tic disorders is limited: no interventions are proven to prevent or stop the disorder exist, and most treatments focus solely on tics, though other symptoms often affect quality of life more than tics. To develop new treatments and improve care for people with tics, researchers need to better understand the different symptoms people experience and how the brain causes these symptoms.
Many individuals with tic disorders have sensory and movement symptoms other than tics. A common sensory symptom is increased sensitivity to common sensations, such as glare from sunlight, tags in shirt collars, and noises from passing cars. A common movement symptom is poor handwriting and/
Sign in to get the eligibility rules as simple questions to take to your doctor.
📋 Eligibility rules (as published)
* Inclusion criteria for adolescents with tic disorder:
* adolescent age 11-17 years of age
* adolescent diagnosis of chronic tic disorder (Tourette syndrome, chronic motor tic disorder, chronic vocal tic disorder)
* English-speaking adolescent and caregiver/adult proxy (as validated questionnaires are in English)
* adolescent and caregiver/adult proxy willingness and ability to complete relevant questionnaires
* Exclusion criteria for for adolescents with tic disorder:
* cognitive or attentional impairment precluding ability of adolescent or caregiver/adult proxy to complete questionnaires and other study measures
* adolescent diagnosis of autism spectrum disorder (ASD) or psychotic disorder
* adolescent diagnosis of pervasive genetic disorder besides chronic tic disorders and their known comorbidities
* adolescent with severe medical conditions unrelated to chronic tic disorders (e.g. uncontrolled seizures, prominent heart conditions)
* other variables that might influence ratings outside of the typical presentation of chronic tic disorders
* Additional exclusion criteria for EEG tasks for chronic tic disorder sample\*\*
* adolescent treatment with stimulant medications or anti-seizure medications within the past 30 days
* use of marijuana or recreational substances within the past 30 days
* history of seizure
* history of hearing loss or abnormalities
* history of neuropathy or overt sensory deficit
* history of brain surgery or skull-penetrating/deforming trauma
* history of stroke, brain cancer, or other significant neurologic illness/disorder \*\* Individuals excluded based on these criteria are ineligible for the EEG portion of the study but can complete the remainder of the study measures.
* Inclusion criteria for control (neurotypical adolescent) participants
* adolescent age 11-17 years of age
* English-speaking adolescent and caregiver/adult proxy (as validated questionnaires are in English)
* adolescent and caregiver/adult proxy willingness and ability to complete relevant questionnaires
* Exclusion criteria for control sample
* history of tics, ADHD, OCD, or other significant neurodevelopmental or neuropsychiatric disorder.
\*\* Note: adolescents with history of mood or anxiety disorder are eligible.
* cognitive or attentional impairment precluding ability of adolescent or caregiver/adult proxy to complete questionnaires and other study measures
* adolescent diagnosis of autism spectrum disorder (ASD) or psychotic disorder
* adolescent diagnosis of pervasive genetic disorder
* adolescent with severe medical conditions (e.g. uncontrolled seizures, prominent heart conditions)
* other variables that might influence ratings
* Additional exclusion criteria for EEG tasks for control sample\*
* adolescent treatment with stimulant medications or anti-seizure medications within the past 30 days
* use of marijuana or recreational substances within the past 30 days
* history of seizure
* history of hearing loss or abnormalities
* history of neuropathy or overt sensory deficit
* history of brain surgery or skull-penetrating/deforming trauma
* history of stroke, brain cancer, or other significant neurologic illness/disorder
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