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The HEROES Trial: Hyperbaric Oxygen Therapy for Endometriosis-Related Pain

RecruitingNAAges 18 Years - anyAllSunnybrook Health Sciences Centre
NCT06579040 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Endometriosis, is a condition where tissue from the uterus, called endometrium, grows outside of the uterus. This effects up to 10% of women, and can lead to long-lasting, moderate to severe pelvic pain, infertility and other symptoms. This can affect a woman's quality of life (including increased risk of depression and anxiety) and is associated with increased healthcare costs. Current treatments are often limited by serious side effects, and many women resort to surgery. Surgery is also associated with complications and there are long wait times for procedures, sometimes over 3 years. This means that many women continue to suffer from symptoms while they wait for surgery. Therefore, new effective treatments for endometriosis pain are needed. New research suggests that inflammation and stress caused by lack of oxygen in the affected areas may cause endometriosis. Hyperbaric Oxygen The

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age ≥ 18 years old * Patients having refractory pelvic pain (NRS≥4) secondary to endometriosis for \>6 months * May or may not be on traditional multi-modal treatment (pharmacological and/or non-pharmacological) * On waitlist for surgical treatment Exclusion Criteria: * Patients with chronic pain resulting from disease processes unrelated to the pathophysiology of endometriosis-related symptoms (e.g. irritable bowel syndrome, migraine headache, fibromyalgia, chronic low back pain, and musculoskeletal injuries) * Contraindications/medically unfit to receive hyperbaric treatments at an outpatient facility (e.g. pneumothorax, in-patients, requiring infusions to maintain hemodynamics, active and unstable coronary disease) * Unlikely to comply with follow-up assessments (e.g. no fixed address, plans to move out of town)
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What it tests

  • Monoplace Hyperbaric Chamber (Class III medical device)
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Where

1 site
Sunnybrook Health Sciences Centre
Toronto, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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