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Study of Vitamin B12 Metabolism in Children With Sickle Cell Disease Exposed to MEOPA

Recruitingn/aAges 2 Years - 18 YearsAllCHU de Reims
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In plain words

What the trial is, and whether it could suit you

Short description of the protocol intended for the lay public. Include a brief statement of the study hypothesis (Limit : 5000 characters) The sickle cells anemia is a monogenic disease linked to the presence of Hemoglobin S due to a mutation in the Hemoglobin Beta chain. The lack of circulating oxygen induces a polymerization of the Hemoglobin S which change the red cell conformation into sickle. Those cells interact and causes vaso-occlusive crisis (CVO). The MEOPA is a medical gas used as an antalgic and a sedative especially in sickle cells disease patients. The nitrous oxide, oxide the cobalt ion in the vitamin B12 which inactivate it irreversibly creating a functional deficiency. During the metabolism of vitamin B12, homocysteine is transformed in methionine which is used in to form the myelin sheath and helped in producing DNA. Numerous studies already shown that the longer the

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Sickle cells patient * Age between 2 and 18 years old * Being affiliated with social security Exclusion Criteria: * Having a neurological defect prior to the study * Being against the collection of blood or data
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What it tests

  • Vitamin B12
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Where

1 site
Chu Reims
Reims, France
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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