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Comparative Study Between Photodynamic Therapy with LED Associated with Probiotics in the Treatment of Halitosis

RecruitingPhase 1Ages 18 Years - 60 YearsAllUniversity of Nove de Julho
NCT06583720 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Halitosis is a term that defines any odor or bad smell coming from the oral cavity, which can have a local or systemic origin. This project aims to verify if there is a difference in the effectiveness of treatment with antimicrobial photodynamic therapy (aPDT) with LED associated with treatment using probiotics in reducing halitosis. 92 participants, aged 18 to 60 years, diagnosed with halitosis, presenting sulfhydride (SH2) ≥ 112 ppb in gas chromatography will be selected. Participants will be randomly divided into 4 groups (n=23), which will receive different treatments: Group 1 (control): brushing, dental floss and tongue scraper; Group 2: brushing, dental floss, tongue scraper and aPDT with blue LED and annatto; Group 3: brushing, dental flossing, tongue scraper and aPDT with blue LED, annatto and probiotic lozenges containing Streptococcus salivarius K12 (BLIS K12®); Group 4: brushi

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📋 Eligibility rules (as published)
Inclusion Criteria: * Diagnosis of halitosis showing sulfhydride (SH2) ≥ 112 ppb in gas chromatography. Exclusion Criteria: * Individuals with dentofacial anomalies (such as cleft lip, cleft palate and nasopalatine); * Undergoing orthodontic and/or orthopedic treatment; * Undergoing oncological treatment; * With systemic alterations (gastrointestinal, renal, hepatic) * Undergoing antibiotic treatment up to 1 month before the research; * Pregnant women.
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What it tests

  • Oral hygiene at home
  • aPDT
  • Probiotics
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Where

1 site
Nove de Julho University
São Paulo, Brazil
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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