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Venoactive Drug Treatment of Pelvic Venous Disorders

RecruitingPhase 3Ages 18 Years - 45 YearsFemalePirogov Russian National Research Medical Univers…
NCT06584799 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Venoactive drug (VAD) therapy is one of the most effective methods of treating chronic venous diseases (CVD). Numerous studies have proven its high efficacy in relieving symptoms of CVD, such as leg pain and swelling, leg heaviness and fatigue. Pelvic venous disorders (PeVDs) represent a group of pathological conditions including varicose veins of the pelvis and vulva, and compression stenoses of the left renal and common iliac veins. Although PeVDs are associated with venous lesions of the pelvis and retroperitoneum and have specific clinical manifestations, they are one of the forms of CVD and constitute a separate cohort. A number of studies on the VAD usage in PeVD indicate the wide possibilities of this type of treatment in eliminating chronic pelvic pain (CPP), the most dramatic symptom of PeVD, which is the main cause of disability and decreased quality of life, social and daily a

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age from 18 to 45 years; * The presence of PeVD symptoms (CPP, dyspareunia, discomfort in the hypogastrium, dysuria, vulvar varicose veins); * The presence of pelvic varicose veins with reflux in them, according to DUS; * Pelvic venous reflux (PVR) lasting for greater than 1 s, according to DUS; * Isolated dilation and reflux in the parametrial and uterine veins, according to DUS; * Absence of competing abnormalities, accompanied by CPP. Exclusion Criteria: * Asymptomatic form of the disease; * Menopause; * Pregnancy; * Post-thrombotic disease; * Neoplasms; * Competing diseases with CPP; * Known hypersensitivity to any of the components of the used VAD.
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What it tests

  • Micronized purified flavonoid fraction
  • Diosmin 600
  • Hesperidin+Diosmin combination 1000
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Where

1 site
Pirogov Russian National Research Medical University
Moskva, Russia
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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