💬In plain words
What the trial is, and whether it could suit you
The focus of this study is to understand and define the mechanisms of the altered muscle development and growth on a microscopic level within a long-term perspective in children with cerebral palsy and to relate these findings to muscle macroscopic properties defined by muscle imaging, to neuromuscular symptoms and to treatment.
This study aims to (1) evaluate intrinsic microscopic muscle properties of young growing children with CP, and (2) to evaluate these muscle properties in relation to macroscopic properties, neuromuscular symptoms and to treatment.
Improved understanding of changes in microscopic muscle properties, and how they relate to macroscopic properties and to the neuromuscular symptoms as well as how they are influenced by treatment, has the potential to delineate CP phenotypes prone to intervention and to optimize treatment protocols or develop new treatments, leading t
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📋 Eligibility rules (as published)
CHILDREN WITH CP
Inclusion criteria
* Children (boys/girls) diagnosed with predominantly spastic type of CP
* Uni- or bilateral involvement
* Gross Motor Function Classification Scale (GMFCS) Level I-III50
* 2 to 9 years of age
* Planned for an orthopedic intervention that requires general anesthesia (botulinum toxin injections, orthopedic surgery, or diagnostic imaging such as Magnetic Resonance Imaging \[MRI\], etc.)
Exclusion criteria
* Presence of dystonia or ataxia
* Previous surgery less than 6 months at the investigated muscles
* Severe co-morbidities (that are likely to prevent proper assessment, such as severe cognitive problems)
TYPICALY DEVELOPING CHILDREN
Inclusion criteria
* Children (boys/girls)
* 2 to 9 years of age
* Planned for a surgical intervention that requires general anesthesia (pure pediatric upper limb orthopedic surgery or trauma surgery, or ophthalmic or ear-nose-throat surgery)
Exclusion criteria
* History of neurological problems
* History of orthopedic problems at the gastrocnemius or semitendinosus
* Trauma at the level of the lower limbs
* Involvement in an elite or high-performance sporting program (Children performing sports for \> 3 5 hours/week will be excluded)
ADOSESCENTS WITH HSP of 12-18 years old and ADULTS WITH HPS
Inclusion criteria
* Adolescents (boys/girls) or adults (male/female) diagnosed with HSP, SPG3a or SPG4
* Gross Motor Function Classification Scale (GMFCS) Level I-III50
* Adolescents 12 to 18 years or adults 18-40 years of age
Exclusion criteria
* Presence of dystonia or ataxia
* Previous surgery less than 6 months at the investigated muscles
* Severe co-morbidities (that are likely to prevent proper assessment, such as severe cognitive problems)
TYPICALLY DEVELOPING ADOLESCENTS of 12-18 years old and HEALTHY ADULTS (age- and gender-matched with the recruited HSP patients)
Inclusion criteria
* Typically developing adolescents (boys/girls) and healthy adults (male/female), who are age and gender matched with the recruited HSP participants
* Adolescents 12-18 years of age or adults 18-40 years of age
Exclusion criteria
* History of neurological problems
* History of orthopedic or muscular problems at the gastrocnemius
* Trauma at the level of the lower limbs
* Involvement in an elite or high-performance sporting program (participants performing sports for \> 5 hours/week will be excluded)
* Sport session less than 72 hours prior to the biopsy collection
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