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a PRagmatic Observational Study of Congestion proFILes in patiEnts With Acute Heart Failure

Recruitingn/aAges 18 Years - anyAllUniversity Medical Center Groningen
NCT06587854 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this observational is to study the prevalence of distinct congestion phenotypes and study their association with response to therapy and outcomes in acute heart failure patients. The main question\[s\] it aims to answer \[is/are\]: * Primary objective: to study the prevalence of distinct congestion phenotypes * Other objectives (including): * Response to therapy as assessed by * Natriuresis after 24 hours * Rehospitalization and/or deats after 6 months * Length of hospital stay * Congestion at discharge * Changes in filling pressures over time * Relationship between liver stiffness, as assessed with Fibroscan and congestion * Substudy: glycosaminoglycan netword and endothial glycocalyx Participants will undergo several extra study related measurements: * Assessment of filling pressures with ultrasound * Ultrasound investigation of the lungs and kidney

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📋 Eligibility rules (as published)
Inclusion Criteria: * Able and willing to give written informed consent * Age ≥ 18 years * Male or female * Primary diagnosis of acute heart failure at presentation, with signs and symptoms of tissue decongestion. Diagnosis is based on the criteria in the ESC HF guidelines (1) * Requirement of intravenous loop diuretics Exclusion Criteria: * Patients with severe kidney dysfunction (in need for ultrafiltration or dialysis) * Previous participation in this study * Inability to follow instructions * Dyspnoea or oedema primarily due to non-cardiac causes
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What it tests

  • Not listed
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Where

1 site
UMCG
Groningen, Netherlands
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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