AI Cure is a research tool showing open data. Not medical advice. Discuss with your doctor. Terms

โ† Trials
๐Ÿงช

Detection of Homologous Recombination Pathway Gene Mutations in Circulating Tumour DNA From BRCA-mutated Ovarian Cancer Patients Receiving First-line PARP Inhibitor Maintenance Therapy

RecruitingNAAges 18 Years - anyFemaleInstitut Claudius Regaud
๐Ÿ’ฌ

In plain words

What the trial is, and whether it could suit you

This is an interventional (category 2), prospective, multicentric cohort study designed to demonstrate that the search, based on Circulating tumour DNA analysis, for a BRCA1/2 reversion mutation leading to restoration of its protein function enables early identification of disease progression in BRCA1/2 mutant patients treated as first-line maintenance with a PARP inhibitor (Olaparib alone or in combination with bevacizumab) for ovarian cancer. For this study, a total of 9 blood samples will be taken from patients who will undergo a full 24-month treatment regimen. Apart from the study procedure (blood sampling), all examinations carried out in this study, treatment with Olaparib (alone or combined with bevacizumab) and patient follow-up procedures will be carried out as part of routine care in accordance with the standard practices of each investigating site. 130 patients will take p

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: 1. Patient with an epithelial ovarian cancer, fallopian tube cancer or primitive of the peritoneum. 2. Patient with a BRCA 1 or 2 somatic and/or constitutional mutation previously confirmed and validated by an approved laboratory. 3. Patient due to start first-line maintenance treatment with Olaparib alone (PARP inhibitor) or in combination with bevacizumab. 4. Age โ‰ฅ 18 years at the time of signing the consent. 5. WHO โ‰ค 1. 6. Patient affiliated to a Social Security scheme in France. 7. Patient having signed informed consent prior to inclusion in the study and prior to any specific procedure for the study. Exclusion Criteria: 1. Other cancer under treatment. 2. Olaparib treatment already initiated. 3. Indication for treatment with a PARP inhibitor other than Olaparib. 4. Any pathology contraindicating the sample collection procedures required by the study. 5. Any psychological, family, geographical or sociological condition that makes it impossible to comply with medical monitoring and/or the procedures laid down in the study protocol. 6. Subjects deprived of their liberty or under legal protection.
๐Ÿ’Š

What it tests

  • Blood samples will be taken on several times (36 mL of blood taken at each time):
๐Ÿ“

Where

6 sites
INSTITUT DE CANCEROLOGIE DE L'OUEST - Site Angers
Angers, France
Institut Bergonie
Bordeaux, France
Chu de Limoges
Limoges, France
Chu de Nimes
Nรฎmes, France
INSTITUT DE CANCEROLOGIE DE L'OUEST - Site Saint-Herblain
Saint-Herblain, France
IUCT-O
Toulouse, France
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
๐Ÿ›ก๏ธ

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it โ€” not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use ยท Privacy