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The STatus Epilepticus Prognosis Study

Recruitingn/aAges 18 Years - 80 YearsAllLondon Health Sciences Centre Research Institute …
NCT06590883 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this study is to improve the prognosis of patients who present with Status Epilepticus (SE). In the first part of this study, the investigators aim to find better markers of good and poor outcomes of SE patients while in the ICU. The objective is to measure the levels of brain protein micro-particles that are detectable in blood samples. The investigators seek to determine whether elevated levels of micro-particles in the bloodstream in SE patients can be used to predict the eventual outcome of survivors. The goal of the second part of the study is to evaluate long-term cognitive outcomes in survivors of SE To date, there is no reliable information to inform what cognitive recovery is like for survivors of SE after ICU discharge. The objective is to use the Creyos cognitive testing platform to assess different domains of cognitive function for up to 1 year after SE onset. Pat

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📋 Eligibility rules (as published)
Inclusion Criteria: * 18 to 80 years of age * SE requiring admission to critical care * Developed SE while in ICU * No history of a neurologic condition, other than epilepsy, that would impact cognition (Dementia, Parkinson's disease, Alzheimer's disease) * Absence of devastating neurologic injury (cardiac arrest, stroke, traumatic brain injury) In addition, for non-SE epilepsy controls for Creyos task: * People with epilepsy * No history of status epilepticus * Patient has not stereotaxic EEG monitoring * English speaking * No history of a neurologic condition, other than epilepsy, that would impact cognition (Dementia, Parkinson's disease, Alzheimer's disease) In addition, for follow up MRI purposes only: * Diagnosed with refractory status epilepticus while in ICU * No MRI contraindications (metal in body, pacemakers, etc.) Inclusion Criteria Healthy Control Population for MRI imaging: * No history of a neurologic condition that would impact cognition (Dementia, Parkinson's disease, Alzheimer's disease) * No MRI contraindications (metal in body, pacemakers, etc.) Exclusion Criteria: * patients not meeting inclusion criteria * acute brain injury or brain tumour as immediate cause of status epilepticus
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What it tests

  • Not listed
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Where

1 site
Lawson Health Research Institute
London, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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