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Hemodynamic Monitoring and Fluid Responsiveness in Venovenous Extracorporeal Membrane Oxygenation (VV ECMO) - "HemodynamECMOnitoring-VV Study"

RecruitingNAAges 18 Years - 75 YearsAllMedical University of Vienna
NCT06593717 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

In extracorporeal membrane oxygenation (ECMO), blood is drawn out of the body via tubes, oxygenated in an artificial lung; and then pumped back into the blood vessels. This allows the supply of oxygen-rich blood to the organs (brain, heart, lungs, kidneys, liver, intestines, etc.) to be maintained. Continuous monitoring of cardiac function and circulatory status (blood pressure, blood flow to organs) is very important in intensive care medicine in order to control the administration of circulation-supporting medication and infusions. Various devices are routinely used for this task. However, in the specific situation of ECMO treatment, the measurements of these devices could be affected due to the artificial circulation; outside the body. The purpose of this study is therefore to test the accuracy of different methods of circulation monitoring during ECMO treatment.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patient receiving VV-ECMO support * Age 18 - 75 years Exclusion Criteria: * Pregnancy * Conditions not allowing for passive leg raising maneuvers, e.g. "open abdomen", known or suspected elevation of intracranial pressure, recent leg or spinal trauma or orthopedic conditions not permitting leg raising * Known ischemic or hemorrhagic stroke within 3 months prior to study enrollment. Suspicion of raised intracranial pressure is defined as pupil divergence (if not yet further clarified radiographically/neurologically/ophthalmologically) or signs detected in routine computed tomography scans (compressed or elapsed basal cisterns or midline shift \> 5 mm.
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What it tests

  • Transthoracic Echocardiography
  • Uncalibrated Pulse Contour Analysis
  • Transpulmonary Thermodilution/Calibrated Pulse Contour Analysis
  • Esophageal Doppler
  • Bioreactance
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Where

1 site
Medical University of Vienna
Vienna, Austria
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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