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Atezolizumab and BEvacizumab With STereotactic Body Radiotherapy for Advanced Hepatocellular Carcinoma

RecruitingNAAges 19 Years - 80 YearsAllYonsei University
NCT06595108 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

To determine the efficacy and safety of atezolizumab-bevacizumab combination therapy plus stereotactic body radiotherapy(SBRT) in patients with advanced hepatocellular carcinoma, Subjects will start SBRT for one or more primary cancers and/or metastatic lesions and no more than 5 sites within two month before and after the start date of atezolizumab-bevacizumab combination therapy. In this study, it is expected to improve the treatment response rate of atezolizumab-bevacizumab therapy, which is currently first-line chemotherapy but has a low treatment response rate.

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Age 19 to 80 years old 2. Liver function Child-Pugh class A 3. ECOG 0-1 4. Patient clinically or pathologically diagnosed with hepatocellular carcinoma 5. Advanced hepatocellular carcinoma that is inoperable 6. Satisfies the dose limits for normal organs and lesions of an appropriate size to be included in the scope of radiotherapy. Exclusion Criteria: 1. Brain metastases 2. Have a history of malignancy other than hepatocellular carcinoma within the last 5 years (except for malignancies with little risk of metastasis or death, e.g., adequately treated cervical carcinoma in situ, non-melanoma skin cancer, localized prostate cancer, tubular carcinoma in situ, or stage 1 uterine cancer.) 3. Subjects with a high probability of untreated gastric or esophageal varices or bleeding 4. Serious uncontrolled medical comorbidities 5. History of liver transplant surgery 6. Autoimmune liver disease
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What it tests

  • Stereotactic body radiotherapy
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Where

1 site
Yongin Severance Hospital
Yongin-si, South Korea
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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