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Breast cancEr, FITness and ExeRcise for Heart Health: The BE-FITTER Study

RecruitingNAAges 60 Years - anyFemaleUniversity of Alberta
NCT06595147 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The chemotherapy medications used for breast cancer treatment are important for achieving a cure, but a potential side effect is that they can cause a decline in functional capacity (reduced exercise tolerance and impaired physical function) and increase the risk of cardiovascular disease. The risks of decreased functional capacity and cardiovascular disease are highest in breast cancer survivors as they grow older. The factors causing the decline in functional capacity are not well understood, however they may be related to a reduction in cardiac function (e.g. decreased pumping ability of the heart) or skeletal muscle function (reduced muscle blood flow and oxygenation). Exercise training is used for other populations at risk for cardiovascular disease (such as cardiac rehabilitation), but is not routinely offered to breast cancer survivors. Therefore this research study wants to test

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age ≥60 years * Previously diagnosed with early-stage (I-III) BC * Completed (≥1 year post) primary cardiotoxic treatment (anthracycline-based chemotherapy or trastuzumab-based biological therapy). Exclusion Criteria: * Have a history of coronary artery disease, heart failure, persistent and permanent arrhythmia (e.g. currently in atrial fibrillation), stroke, or chronic obstructive pulmonary disease * Develop signs or symptoms of myocardial ischemia (≥1mm horizontal or down-sloping ST segment depression on electrocardiogram) during the cardiopulmonary (VO2peak) test * Have any research MRI contraindications (e.g. any type of pacemaker), or any orthopedic limitation preventing exercise testing * Currently performing structured exercise training (defined as ≥30 mins/day of moderate-to-vigorous aerobic and/or resistance exercise training on ≥4 days/week) * Are unwilling to be randomized to either ExT or STRETCH
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What it tests

  • Structured Exercise Training
  • Group-based Yoga and Stretching
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Where

1 site
University of Alberta
Edmonton, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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