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Differential Assessment of Hypertonia

RecruitingNAAges 20 Years - anyAllChang Gung University
NCT06596187 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Spasticity and rigidity are common symptoms of central nervous system injuries, such as spinal cord injury and Parkinson's disease, and result in distinct patterns of increased resistance during passive joint movements. Spasticity is characterized by a velocity-dependent increase in stretch reflexes, accompanied by exaggerated tendon responses, while rigidity is marked by consistent resistance throughout the range of motion, traditionally considered independent of stretch velocity. However, recent studies suggest that rigidity may also be influenced by stretch velocity. This study aims to investigate muscle tone by examining spasticity, rigidity, and normal muscle function through neural and biomechanical changes. Standard clinical tools, such as the Modified Ashworth Scale and Unified Parkinson's Disease Rating Scale, along with additional assessments like the Myoton and Post-Activation

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📋 Eligibility rules (as published)
Health subjects: Exclusion Criteria: 1. Musculoskeletal injuries on legs. 2. Osteoporosis. SCI subjects: Inclusion Criteria 1. Participants with chronic spinal cord injury, with injury duration greater than one year. Exclusion Criteria 1. Current musculoskeletal or joint injuries in the lower limbs. 2. History of central or peripheral neuromuscular diseases. 3. Presence of a pacemaker. 4. Current use of antispastic or antidepressant medications. 5. Current venous thromboembolism or osteoporosis. 6. Impairment of the soleus H-reflex arc. PD subjects: Inclusion Criteria: \- Clinical diagnosis of Parkinson disease. Exclusion Criteria: 1. Musculoskeletal injuries on legs 2. Osteoporosis. 3. Any peripheral or central nervous system injury or disease patients.
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What it tests

  • Continuous passive motion device (CPM) of ankle - fast
  • Continuous passive motion device (CPM) of ankle - slow
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Where

1 site
Chang Gung University
Taoyuan, Taiwan
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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