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Effect of Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) on Plasma Insulin Levels

RecruitingNAAges 18 Years - 70 YearsAllIndiana University
NCT06597149 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The vagus or vagal nerve is a nerve that sends signals from the brain to other parts of the body to control involuntary functionm, including stomach function, and it is important to the regulation of insulin, C-peptide, and glucose levels. The purpose of this study is to evaluate whether electrically stimulating the nerve around the external ear will also stimulate the internal vagus nerve and influence the levels of insulin, C-peptide, and glucose. If it does, investigators hope that this will help innovate treatment of patients with nausea, vomiting, and disordered stomach function, and patients with diabetes.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Healthy Volunteers * Aged 18-70 * Willing to have ECG electrodes placed on their neck and chest areas. * Willing to have electrodes placed in the external ear. * Willing to have an indwelling catheter placed to avoid multiple sticks for blood draw. Exclusion Criteria: * Unable to provide consent. * Diabetes diagnosis per patient report * Having known allergies to adhesive on electrode pads or bandages * Having gastric motility issues as determined by the PI or clinical coordinator. * Taking any medications that may affect gastric motility or cardiac variability, i.e. alpha or beta blockers for hypertension. * Pregnant females * Those unwilling to have the taVNS device placed in their ear. * Those unwilling to consent to a blood draw. * Prisoners
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What it tests

  • Transcutaneous Auricular Vagus Nerve Stimulation
  • Sham Procedure (No Stimulation)
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Where

1 site
Indiana University Hospital
Indianapolis, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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