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Novel Therapeutic Approach for Human T-cell Malignancies

Recruitingn/aAges 18 Years - anyAllIstituto Oncologico Veneto IRCCS
NCT06600568 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This multicenter translational study, with prospective and retrospective samples, aims to identify new strategies to selectively eliminate neoplastic T cells by modulating intracellular ROS levels. Interactions between drugs capable of activating the apoptotic process (e.g., Venetoclax) and drugs capable of altering ROS homeostasis (e.g., inhibitors of the enzyme glucose-6-phosphate dehydrogenase) will be examined. The most promising compounds will be selected based on results obtained in vitro on cell lines and PDX already available in the laboratory, and then will be assayed ex vivo in cells obtained from patients with resistant/refractory T-cell neoplasms.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients with pre- and post-thymic T-cell leukemia/lymphoma * Patients of both sexes * Age of patients older than 18 years * Patient is willing to provide written and signed informed consent for participation in the study Exclusion Criteria: -Serious illness or medical condition that does not allow the patient to be managed according to standard treatment protocols, including uncontrolled active infection.
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What it tests

  • Translation analysis
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Where

2 sites
Istituto Nazionale Tumori Fondazione G.Pascale
Naples, Italy
Istituto Oncologico Veneto
Padova, Italy
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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