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IDENTIFICATION OF BIOMARKERS ASSOCIATED WITH THE SEVERITY AND RADIO-CLINICAL PROGRESSION OF KNEE OSTEOARTHRITIS

Recruitingn/aAges 18 Years - anyAllAssistance Publique - Hôpitaux de Paris
NCT06600958 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Knee osteoarthritis (OA) is an heterogeneous disease, both symptomatically and structurally, with very different evolving profiles. Although several serum, urinary or synovial biomarkers have been developed in knee OA, their interest as potential predictive factors of clinical and structural progression remains poorly known. Similarly, to date, no biological predictive markers of response to OA treatments have been validated, particularly for intra-articular treatments \[corticosteroids (CTC), hyaluronic acid (HA), platelet-rich plasma (PRP)\]. Finally, although cohorts of OA patients have already been established in the past, none of them has made it possible to establish a biobank of serum and synovial fluid obtained from the same patient at inclusion but also during the follow-up of the OA disease, up to the joint replacement. The investigators hypothesize that some biomarkers in ser

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📋 Eligibility rules (as published)
Inclusion Criteria: * \- Male or female * Age ≥ 18 years * Information and consent of the patient or of a third person in case of physical incapacity to sign the consent form * Unilateral or bilateral symptomatic knee OA (both knees may be included at the same time or at different times) regardless of the level of pain, confirmed radiologically by X-ray dating less than one year \[(Kellgren and Lawrence score ≥2 in at least one of the 3 compartments (medial, lateral or patellofemoral)\] or arthritis of the knee related to a spondyloarthritis or rheumatoid arthritis * Registered at the social security system Exclusion Criteria: * Male or female * Age ≥ 18 years * Information and consent of the patient or of a third person in case of physical incapacity to sign the consent form * Unilateral or bilateral symptomatic knee OA (both knees may be included at the same time or at different times) regardless of the level of pain, confirmed radiologically by X-ray dating less than one year \[(Kellgren and Lawrence score ≥2 in at least one of the 3 compartments (medial, lateral or patellofemoral)\] or arthritis of the knee related to a spondyloarthritis or rheumatoid arthritis * Registered at the social security system
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What it tests

  • SA brief descriptive name used to refer to the intervention(s) studied
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Where

1 site
Henri Mondor
Créteil, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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