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Optimizing Prevention and Care for Pregnant and Postpartum Adolescent Girls and Young Women With HIV in Tanzania

RecruitingNAAges 15 Years - anyFemaleKarolinska Institutet
NCT06605053 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to find better ways to care for pregnant and postpartum adolescent girls and young women (AGYW) aged 15-24 years with HIV in Tanzania, and to prevent them from passing HIV to their babies. The main questions it aims to answer are: * How often do young pregnant women with HIV go to their health appointments and stay on their treatment up to two years after giving birth? * How many babies born to young women with HIV stay HIV-free for two years? * How soon do young women with HIV get pregnant again after giving birth, and what factors affect this? * What are the best ways to help young women with HIV stay in care and stay healthy during and after pregnancy? * What social and structural factors affect whether young pregnant women with HIV go to their health appointments and stay on their treatment? * How can we work with young women with HIV to create and

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📋 Eligibility rules (as published)
Sub-study 1 (registry-based cohort analysis): Inclusion Criteria: * Pregnant/postpartum adolescent girls and young women (AGYW) with HIV aged 15-24 years, who started PMTCT services between January 1, 2018, and December 31, 2020. * Infants born to the included AGYW during this period. Exclusion Criteria: * AGYW whose ART (Antiretroviral Therapy) status was not recorded. * Women who had not started ART. Sub-study 2 (qualitative): Inclusion Criteria: * AGYW living with HIV who are currently pregnant, previously pregnant/postpartum, and never pregnant). * HCPs (Health Care Providers) at clinics providing PMTCT services. * Spouses/partners/parents of AGYW and community stakeholders within the study setting. Exclusion criteria \- Mentally or severely ill individuals unable to participate in the study activities. Sub-study 3 (co-production) Inclusion criteria: * AGYW, HCPs, spouses/partners, parents, and community stakeholders who participated in the qualitative study II. * Research team members. Exclusion criteria: \- Mentally or severely ill individuals unable to participate in the study activities. Sub-study 4 (cluster-randomized implementation trial) Inclusion criteria: \- Pregnant AGYW living with HIV (new, previously diagnosed, and transfers) receiving vertical HIV prevention services in routine healthcare between January 1, 2026, and June 30, 2026, and followed up for at least one year until June 30, 2027. Exclusion criteria: * AGYW whose ART (Antiretroviral Therapy) status was not recorded.
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What it tests

  • Co-produced intervention to optimize PMTCT care engagement
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Where

2 sites
Management and Development for Health
Dar es Salaam, Tanzania
Management and Development for Health
Kagera, Tanzania
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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