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Understanding the Transition from Normal Melanocytes to Nevus to Melanoma

Recruitingn/aAges any - anyAllFundacion Clinic per a la Recerca Biomédica
NCT06605417 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The primary objective of this study is to identify the molecular identity profiles of all cellular states that characterize the progression from benign nevi to malignant melanoma in CAYA patients with L/GCMN. The secondary objectives are: * To longitudinally characterize the cell-free DNA (cfDNA) from CAYA patients. * To improve the early diagnosis and treatments for intermediate conditions such as L/GCMN through evidence-based interpretation of personal risk from endogenous or exogenous sources. * To test pre-clinical strategies to best model and improve patient response.

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📋 Eligibility rules (as published)
Inclusion criteria: * Congenital nevus with estimated size of 20 cm * Be over 18 years of age Exclusion criteria: * No available biological material * Not having signed the informed consent
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What it tests

  • Methylomics
  • RNA sequencing
  • Spatial transcriptomics
  • Liquid biopsy
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Where

2 sites
French National Institute of Health and Medical Research
Marseille, France
Hospital Clínic de Barcelona (Dermatology service)
Barcelona, Spain
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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