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โ† Trials
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Optimized Tailored Interventions in Metabolic and Lifestyle Outcomes (OPTIMAL)

RecruitingNAAges 45 Years - 64 YearsAllUniversity of Illinois at Urbana-Champaign
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to learn if increasing adherence to a Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet pattern improves brain and heart health relative to a healthy control diet in middle-aged adults. Our research team will evaluate three different groups: the first group will be chosen using a predictive analytics model that predicts who will benefit most from the MIND diet, the second group will follow the MIND diet without being pre-selected, and the third group will eat a standard healthy diet to serve as a comparison. The main questions it aims to answer are: Does the MIND diet improve cognitive performance and heart health relative to a control diet? How does the health impact of the MIND diet in participants pre-identified through predictive analytics compare to those without such pre-selection? Which of the three groups - predictive ana

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * 45-64 years of age * 20/20 or corrected vision * No food allergies or intolerances * Not pregnant, lactating, or have given birth in the past 12 months * Do not smoke, use tobacco, or abuse drugs * Absence of liver or gastrointestinal diseases (i.e., primary biliary cirrhosis or gallbladder disease, chronic constipation, diarrhea, Crohn's disease, celiac disease, ulcerative colitis, irritable bowel syndrome, diverticulosis, stomach or duodenal ulcers), hepatitis, HIV, and cancer * Not currently taking oral hypoglycemic agents, or insulin * No history of malabsorptive or bariatric surgery * Cognitively intact with no prior diagnosis of neurological disease (i.e., mild cognitive impairment, Alzheimer's disease, vascular dementia, and/or Asperger's syndrome) * Able to consume the study meals * Not enrolled in another dietary, exercise, or medication study during the study. Exclusion Criteria: * Non-consent of participant * Above 64 or below 45 years of age * Vision not 20/20 or corrected * Food allergies or intolerances * Pregnant, lactating, or have given birth in the past 12 months * Smoke, use tobacco, or abuse drugs * Prior diagnosis of liver or gastrointestinal disease (i.e., primary biliary cirrhosis or gallbladder disease, chronic constipation, diarrhea, Crohn's disease, celiac disease, ulcerative colitis, irritable bowel syndrome, diverticulosis, stomach or duodenal ulcers), hepatitis, HIV, or cancer * Currently taking oral hypoglycemic agents or insulin * History of malabsorptive or bariatric surgery * Cognitively impaired and/or prior diagnosis of neurological disease (i.e., mild cognitive impairment, Alzheimer's disease, vascular dementia, and/or Asperger's syndrome) * Unable to consume the study meals * Concurrent enrollment in another dietary, exercise, or medication study
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What it tests

  • MIND Diet
  • Control Diet
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Where

1 site
University of Illinois at Urbana-Champaign
Urbana, United States
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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