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Multimodal and Multidisciplinary Approach to Optimize Diagnostic, Prognostic, and Therapeutic Management of Patients with Non-ischemic Cardiomyopathies and Arrhythmogenic-inflammatory Phenotypes: a Multicenter, Observational, Retrospective and Prospective Registry Study.

Recruitingn/aAges 18 Years - anyAllScientific Institute San Raffaele
NCT06607471 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Non-ischemic cardiomyopathies (NICM) represent a heterogeneous group of pathologies characterized by absence of obstructive disease of the epicardial coronary vessels and distinct structural and functional changes of the myocardium. The main identified forms include dilated cardiomyopathy (DCM), hypertrophic cardiomyopathy (HCM), restrictive cardiomyopathy (RCM), and arrhythmogenic cardiomyopathy proper (ACM). More recently, further forms of cardiomyopathy have been described, less common and not uniquely classifiable, including: uncompressed myocardium (LVNC), peripartum cardiomyopathy (PPCM), structural correlates of arrhythmogenic mitral valve prolapse (AMVP), Anderson-Fabry disease (AFD), NICM associated with multi- system neuromuscular or autoimmune diseases, lysosomal diseases, glycogenosis, mitochondrial cytopathies and canal diseases with structural substrates. Finally, there are

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📋 Eligibility rules (as published)
Inclusion Criteria: * Written informed consent. For pediatric patients, consent will be obtained by parents, according to the laws applicable in each of the participating countries. * Clinical suspicion of NICM, and/or proven diagnosis of any NICM and/or genotype consistent with any NICM. NICMs will include but not limit to: DCM, HCM, RCM, ACM, inflammatory, infiltrative, dysmetabolic, mitochondrial, toxic, neuromuscular, rheumatologic/autoimmune cardiomyopathies, channelopathies with structural substrates, LVNC, PPCM, AMVP, AFD, athlete's heart, undefined and overlap cardiomyopathies. Additional diseases of the NICM spectrum will be included in parallel with the advance of the current knowledge. Exclusion Criteria: * Absent informed consent. * Proven diagnosis of cardiac disease alternative to NICM. * Lack of diagnostic workup suitable for diagnosing NICM, detecting arrhythmias, or detecting M-Infl. * For patients retrospectively enrolled: lack of active status of follow-up at the enrolling center.
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What it tests

  • Support treatment, cardiac medical treatment, aetiology-specific treatment, device implant, arrhythmia ablation
  • Support treatment, cardiac medical treatment, aetiology-specific treatment
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Where

1 site
IRCCS San Raffaele Scientific Institute
Milan, Italy
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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