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Unveiling the Neural Mechanisms of 5-HT7 in Sleep Apnea Induced by Arousal Dysregulation

Recruitingn/aAges 20 Years - 60 YearsAllBeijing Tsinghua Chang Gung Hospital
NCT06608888 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Obstructive sleep apnea (OSA), recognized as a highly prevalent sleep breathing disorder with severe complications, features a complex etiology. Poor understanding of disease pathogenesis limits the overall efficacy of interventions. Studies have found that upregulation of 5-HT7 expression in the lateral hypothalamus (LH) could reduce arousal threshold (ArTH) and induce an inhibitory effect to the respiratory central, which was associated with hypoxic stimulation. Therefore, the investigators speculate that the structural/functional abnormalities of the arousal-respiratory neural circuit, mediated by LH5-HT7, may play an important role in the pathogenesis of OSA. To verify the hypothesis, the investigators will compare the ArTH and the brain network presenting by multimodal MRI in normal individuals, snoring individuals, and OSA patients, to reveal the correlation between arousal dysregu

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📋 Eligibility rules (as published)
Inclusion Criteria: OSA Patients: * Age between 20 and 60 years. * Symptoms of sleep snoring and daytime sleepiness. * Confirmed diagnosis of OSA following overnight sleep monitoring. Simple Snorers: * Age between 20 and 60 years. * Symptoms of sleep snoring. * Overnight sleep monitoring indicates not meeting the OSA diagnosis. Healthy Controls: * Age between 20 and 60 years. * No symptoms of sleep snoring. * Overnight sleep monitoring rules out the diagnosis of OSA. Exclusion Criteria: * Presence of severe pulmonary, neurological, or cardiovascular complications. * History of long-term non-invasive positive pressure ventilation treatment (more than 3 months) or upper airway surgery. * Sleep-disordered breathing due to special etiologies such as hypothyroidism, acromegaly, vocal cord paralysis, etc. * Presence of severe mental illness, long-term alcohol abuse, or a history of prolonged use of sedative-hypnotic drugs. * Central sleep apnea predominant sleep disorders due to various causes. * Severe craniofacial deformities, myasthenia gravis, or other known myopathic histories. * Patients with peripheral neuropathy caused by diabetes, autoimmune diseases, etc. * Patients with comorbid insomnia, anxiety, depression, or other types of sleep disorders.
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What it tests

  • MRI
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Where

1 site
No. 168 Litang Road, Changping District
Beijing, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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