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Pilot Study to evaluateThrombomodulin to Rule Out Giant Cell Arteritis (GCA) in Polymyalgia Rheumatica (PMR) Patients. (THROPIQ)

Recruitingn/aAges 50 Years - anyAllCentre Hospitalier Universitaire Dijon
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In plain words

What the trial is, and whether it could suit you

Polymyalgia rheumatica (PMR) is a rheumatologic condition occurring in patients \> 50 years old, characterized by inflammatory pain of the scapular (shoulder) and pelvic (hip) girdles. PMR is most often isolated but can be associated with giant cell arteritis (GCA), a large vessels vasculitis, in 16 to 21% of case. The main features of GCA are headaches, jaw claudication, visual disturbances, abnormal temporal artery, scalp tenderness associated to elevated CRP and/or ESR. However, GCA could be asymptomatic in particular in case of isolated involvement of large vessels (subclinical GCA). GCA requires high doses of glucocorticoids, compared to isolated PMR, to avoid complications resulting from vascular remodeling (stroke, blindness). Ruling out GCA in PMR patients relies on the performance of some complementary exams that explore cranial vessels as color doppler ultrasound and/or tempor

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Patient who has given oral consent * Patient \> 50 years of age Patients with PPR, meeting ACR/EULAR 2012 criteria: * age \> 50 years at onset of symptoms * inflammatory limb-girdle pain * elevated ESR (\>20 mm/hr) and/or CRP (\> 10 mg/l) * AND Score โ‰ฅ 4 points among * Morning stiffness \> 45 minutes (2 pts) * Hip pain or limitation of amplitude (1 pt) * Rheumatoid factor or anti-CCP antibodies negative (2 pts) * Absence of other joint pain (1 pt) Exclusion Criteria: * Patient not affiliated to national health insurance * Patient under legal protection (curatorship, guardianship) * Patient subject to a measure of legal safeguard * Pregnant or breast-feeding women * Adult patient unable to provide consent * Patient having received corticosteroid or immunosuppressive treatment in the month prior to inclusion * Patient with a contraindication to corticosteroid therapy * Patients with an active infection, neoplasia or other inflammatory/autoimmune condition * Patients with late onset rheumatoid arthritis. * Conditions rendering vascular imaging unfeasible or uninterpretable: * For angio-CT: allergy to iodine, renal failure (CKD \<30 mL/min) * For PET scan: unbalanced diabetes NB: only one of the two vascular imaging techniques will be performed, depending on the patient\&#39;s condition and the technical resources available. Secondary exclusion criteria: * Final diagnosis of paraneoplastic PMR * Final diagnosis of RA * Negative PET scan (if performed 72 hours after glucocorticoid introduction)
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What it tests

  • Additional blood samples
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Where

1 site
CHU Dijon Bourgogne
Dijon, France
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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