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Naringenin Supplementation in Bone Fracture Patients

RecruitingNAAges 18 Years - 60 YearsAllShahid Beheshti University of Medical Sciences
NCT06612762 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Fractures of the lower extremities represent a significant proportion of injuries sustained by polytrauma patients, with a notable association with prolonged hospitalization, chronic disability, and impaired physical functioning. The occurrence of surgical site infections (SSI) represents a significant threat to the efficacy of osteosynthesis procedures. As with other traumas and surgical procedures, the secretion of inflammatory mediators is markedly elevated in this cohort of patients following surgery. Naringenin is one of the most prevalent flavonoids, occurring naturally in grapefruit and other citrus fruits. In vitro studies have demonstrated that naringenin may stimulate the release of osteogenic cytokines and suppress the production of pro-inflammatory factors, which can result in a reduction in bone resorption. Based on these findings, naringenin may prove an effective agent for

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📋 Eligibility rules (as published)
Inclusion Criteria: * Candidate for orthopedic surgery for bone fractures of the lower limbs, * Ambulatory without assistance for a minimum of two months prior to the fracture. * Not having undergone amputation of the lower limbs. * Not suffering from liver cirrhosis. * Not suffering from advanced kidney failure (blood creatinine higher than 1.4 mg/dL). * Not having metastatic cancer, any chronic inflammatory diseases, nor taking any drugs that affect bone metabolism, including calcitonin, bisphosphonates, and corticosteroids. Exclusion Criteria: * Allergy or intolerant reaction to narangenin capsules * Any abnormal changes in their liver, kidneys tests, * Failure to consume more than 10% of their capsules
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What it tests

  • The daily ingestion of capsules containing naringenin
  • Placebo
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Where

1 site
Ayatollah Taleghani Educational Hospital
Tehran, Iran
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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