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Intravenous Acetaminophen After Cardiac Surgery - Definitive Study

RecruitingPhase 4Ages 18 Years - anyAllMcGill University Health Centre/Research Institut…
NCT06613178 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Double blind, double dummy trial of the use of IV acetaminophen versus oral acetaminophen for the prevention of delirium after cardiac surgery. The underlying hypothesis is that better pain control and less use of narcotics will lead to a lower incidence of delirium from day 1 to 7 following cardiac surgery. Other important secondary outcomes are the total use of narcotics, ICU and hospital stay, improved cognitive function at 6 months and 1 year post surgery, NSAID use at each centre and associated NSAID complications.

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📋 Eligibility rules (as published)
Inclusion Criteria: greater or equal to 18 * elective cardiac surgery * stable pre-operative * aorto-coronary bypass with or without 1 valve replacement. Exclusion Criteria: Refusal by surgeon Requested late extubation by surgeon or anesthesia Intra-aortic balloon pump Mechanical cardiac support Sensitivity to acetaminophen Psychiatric history with current active treatment Alzheimer\'s disease Seizure in previous 6 months Recent history of alcohol misuse Cognitive impairment \-
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What it tests

  • acetaminophen
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Where

8 sites
University of British Columbia
Vancouver, Canada
University of Manitoba
Winnipeg, Canada
Trillium Health Centre
Mississagua, Canada
University of Ottawa
Ottawa, Canada
Sunnybroook Health Centre
Toronto, Canada
McGill Universtiy Health Centre
Montreal, Canada
Universite Montreal
Montreal, Canada
University of Laval
Québec, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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