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Routine vs On-demand ECMO for Lung Transplantation

RecruitingNAAges 18 Years - anyAllCentre hospitalier de l'Université de Montréal (C…
NCT06615492 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Lung transplantation is a complex procedure performed in patients with terminal lung disease. The transplant procedure stresses the patient's heart and lungs, which are already taxed by the underlying disease process. The heart-lung machine is occasionally used to support the patient and ensure adequate oxygen supply to other organs during the operation. It can be used routinely in all patients or selectively in patients who exhibit reduced oxygen supply to the remaining organs. This process, known as cardiopulmonary bypass (CPB), pumps blood out of the body to a heart-lung machine that removes carbon dioxide and returns oxygen-filled blood to the body. Although using the CPB increases the risk of bleeding, infection, and coagulation complications, it should still be considered in high-risk patients to compensate for more severe complications such as kidney failure and stroke caused by

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients undergoing lung transplant surgery Exclusion Criteria: * Inability to provide consent for the study * Retransplantation * Multi-organ transplantation * Contra-indication to standard heparin anticoagulation (e.g., heparin-induced thrombocytopenia) * Lung transplant recipients where intraoperative cardiopulmonary support is mandatory: * Severe pulmonary hypertension (PH): 1. Systolic pulmonary artery pressure (PAP) ≥ 80 mm Hg on the most recent echocardiography, right heart catheterization, or pulmonary artery catheter measurement 2. Mean PAP ≥ 55 mm Hg on the most recent echocardiography, right heart catheterization, or pulmonary artery catheter measurement 3. The ratio of mean pulmonary to systemic artery pressure of \> 0.66 * Moderate to severe right ventricular (RV) hypokinesis or dysfunction * Left ventricular dysfunction: Defined as ejection fraction (LVEF) less than 45% on echocardiography, ventriculography, computed tomography (CT), or magnetic resonance imaging (MRI) * Patients requiring concomitant cardiac surgery: For example, significant coronary artery disease (CAD) requiring surgical grafting
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What it tests

  • Routine ECMO
  • On-demand ECMO
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Where

4 sites
Univeristy of Alberta & Alberta Health Services
Edmonton, Canada
Vancouver General Hospital
Vancouver, Canada
University Health Network / Toronto General Hospiatl
Toronto, Canada
Centre Hospitalier de l'Universite de Montreal
Montreal, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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