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Pilot IntraOperative Neuronal Electrophysiology in Tumor rElatEd suRgery

RecruitingNAAges 18 Years - anyAllErasmus Medical Center
NCT06617208 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

INTRODUCTION AND RATIONALE Aggressive brain tumors like glioma have the ability to infiltrate the surrounding healthy brain tissue, disrupting normal neuronal activities and leading to impaired motor and cognitive functions, as well as causing epilepsy. This malignant brain tumor is considered one of the most challenging cancers to treat, with a median survival of 12 to 15 months. Recent findings on direct neuron-tumor interactions indicate that abnormal brain activity in the regions surrounding brain tumours may contribute to develop epilepsy and accelerating tumor growth. Tumors tend to 'fuel' themselves with neurotransmitters released during its 'daily' neuronal firing. Hyperactive neurons in the peritumoral cortex can form excitatory electrochemical synapses with surrounding tumor cells, creating direct communication pathways within the peritumoral microenvironment, which aids in th

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age \>18 yrs old with radiologically diagnosed brain tumor, suspect for glioma and/or metastasis. * Eligible for surgical resection or biopsy procedure according to standard practice. * Written Informed consent. * Able to undergo intra-operative neuromonitoring. Exclusion Criteria: * History of major psychiatric disorders (e.g., schizophrenia, bipolar disorder, or severe treatment-resistant depression) * Previous brain tumour surgery or radiotherapy. * Patient has pacemaker or other implanted electrical device such as vagal nerve stimulator or other. * Inability to give consent.
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What it tests

  • Neuropixel probe recording
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Where

1 site
Erasmus MC, Department of Neurosurgery
Rotterdam, Netherlands
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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