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Development of a Cognitive Tool for Rapid and Reliable Screening of Minimal Hepatic Encephalopathy: Pilot Study

Recruitingn/aAges 18 Years - 70 YearsAllAssistance Publique - Hôpitaux de Paris
NCT06619106 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The aim of this project is to evaluate the sensitivity and specificity of a cognitive test toward the presence of minimal hepatic encephalopathy (MHE). MHE is a neurological complication due to hepatic dysfunction and/or the presence of porto-systemic shunts defined by the presence of neurocognitive impairments (NI). Other factors of brain injury may cause NI independently from the liver condition making the differential diagnosis difficult using available cognitive tests (ANT Animal Naming Test, PHES Psychometric Hepatic Encephalopathy Score, CFF Critical Flicker Frequency test). The cognitive test evaluated in this project is a construction task using construction blocks, allowing the evaluation of psychomotor speed, executive functions, attention, and episodic memory. The measures will be compared to other cognitive tests validated for the evaluation of the targeted cognitive function

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age between 18 and 70 years * Hepatic pathology (fibrosis, cirrhosis, porto-systemic shunts) * Evaluation at BLIPS clinic (neuropsychological assessment, MRI, EEG and blood sample with ammonia) Exclusion Criteria: * Opposition to participating in the study * Not being affiliated with French healthcare system
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What it tests

  • Cognitive test
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Where

1 site
Hepato-gastro-enterology department, Pitié Salpêtrière hospital
Paris, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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