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A Study to Evaluate Safety, Pharmacokinetics, and Activity of GDC-7035 as a Single Agent and in Combination in Patients With Advanced Solid Tumors

RecruitingPhase 1Ages 18 Years - anyAllGenentech, Inc.
NCT06619587 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This is a first-in-human Phase I/II, open-label, multicenter, dose-escalation and expansion study designed to evaluate the safety, pharmacokinetics, and preliminary activity of GDC-7035 as a single agent and in combination with other anti-cancer therapies in participants with advanced or metastatic solid tumors that harbor the KRAS G12D mutation.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Histologically documented advanced or metastatic solid tumor with KRAS G12D mutation * Agreement to adhere to the contraception requirements described in the protocol for participants of childbearing potential and participants who produce sperm Exclusion criteria: * Malabsorption or other condition that would interfere with enteral absorption * Active brain metastases * Clinically significant cardiovascular dysfunction or liver disease
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What it tests

  • Phase I Arm A
  • Phase I Arm B
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Where

49 sites
UC San Diego Moores Cancer Center
La Jolla, United States
Sarah Cannon Research Institute at HealthONE
Denver, United States
Yale Cancer Center
New Haven, United States
Florida Cancer Specialist-Lake Mary
Lake Mary, United States
University of Illinois
Chicago, United States
Dana Farber Cancer Institute
Boston, United States
START - Midwest - EDOS
Grand Rapids, United States
Montefiore Einstein Cancer Center
The Bronx, United States

…and 41 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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