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Evaluation of Efficacy and Safety of VX-993 for Pain Associated With Diabetic Peripheral Neuropathy

RecruitingPhase 2Ages 18 Years - 80 YearsAllVertex Pharmaceuticals Incorporated
NCT06619860 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The purpose of this study is to evaluate the efficacy, safety, and tolerability of VX-993 in participants with pain associated with Diabetic Peripheral Neuropathy (DPN)

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📋 Eligibility rules (as published)
Key Inclusion Criteria: * Diagnosis of diabetes mellitus type 1 or type 2 with * Glycosylated hemoglobin A1c (HbA1c) less than or equal to (≤) 9% and * Presence of bilateral pain in lower extremities due to DPN (defined as a symmetric, length-dependent sensory or sensorimotor polyneuropathy) for at least 1 year Key Exclusion Criteria: * Painful neuropathy other than DPN * History of cardiac dysrhythmias requiring anti-arrhythmia treatment(s) * History of a clinical atherosclerotic event, such as myocardial infarction or stroke, within the past 12 months Other protocol defined Inclusion/Exclusion criteria may apply.
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What it tests

  • VX-993
  • Pregabalin
  • Placebo (matched to pregabalin)
  • Placebo (matched to VX-993)
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Where

47 sites
Cullman Clinical Trials
Cullman, United States
Trovare Clinical Research - Bakersfield CA
Bakersfield, United States
Eximia Research - San Diego
La Mesa, United States
Paradigm Clincial Research Centers, LLC., Wheat Ridge
Wheat Ridge, United States
Accel Research - Deland
DeLand, United States
AMR Fort Myers (The Clinical Study Center)
Fort Myers, United States
Velocity Clinical Research - Hallandale Beach
Hallandale, United States
Health Awareness, Inc., Jupiter
Jupiter, United States

…and 39 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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