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Treatment of Episodic Migraine With AURICular Neuromodulation

RecruitingNAAges 18 Years - 60 YearsAllHôpital Européen Marseille
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In plain words

What the trial is, and whether it could suit you

Migraine is a ubiquitous pathology affecting approximately 1 billion individuals and being the leading cause of morbidity worldwide before the age of 50. Migraine treatment consists of two main approaches: acute treatment to relieve headache symptoms and preventive treatment to reduce the frequency of migraine attacks by at least 50%. Preventive treatment involves medications such as beta-blockers, antiepileptics, calcium channel blockers, and a new therapeutic class called calcitonin gene-related peptide (CGRP) inhibitors. While traditional treatments have modest efficacy and limited tolerability, CGRP inhibitors have shown better tolerability and superior efficacy. However, their prescription in France is restricted to neurologists and specialized pain evaluation and treatment units. Additionally, the long-term effects of CGRP inhibition on blood pressure control and vascular homeostas

Sign in to get the eligibility rules as simple questions to take to your doctor.

📋 Eligibility rules (as published)
Inclusion Criteria: * 18 years ≥ Aged ≤ 60 years * Moderate to severe Migraine for at least one year * Migraines appeared before the age of 50 and diagnosed according to IHS (international headache society) criteria. * Therapeutic failure of at least 2 migraine preventive medications * Frequency of migraine days ≥ 4 per month and \< 15 per month Exclusion Criteria: * Pathology of the auricle (e.g. epithelioma) * Patient treated with botulinum toxin for migraine ≤ 2 months * Patient treated with anti-cgrp for migraine, with last injection less than 3 months ago * Patient treated with non-invasive auricular stimulation ( TENS)
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What it tests

  • Auricular neuromodulation
  • Sham auricular neuromodulation
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Where

3 sites
BENNANI
Marseille, France
Hôpital Européen Marseille
Marseille, France
Hôpital Européen Marseille
Marseille, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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