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Extensive Resection of Malignant Brain Tumors Using Advanced Imaging Techniques

RecruitingNAAges 18 Years - anyAllAmsterdam UMC, location VUmc
NCT06623565 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Rationale: Patients with IDH-wildtype glioblastoma or grade IV IDH-mutant astrocytoma have a very poor prognosis despite standard treatment consisting of surgery, radiotherapy, and chemotherapy. Diffuse infiltration of the brain by the tumor is thought to be one of the main causes of this therapy-resistance. In order to improve the surgical treatment, tumor regions with lower infiltration percentages need to be identified and resected during surgery, a so-called supramarginal resection. Currently, pre-operative T1 contrast enhanced weighted (T1c) MRI is used to identify the tumor for resection. We recently found the combination of apparent diffusion coefficient MRI and O-(2-\[ 18F\]fluoroethyl-)-L-tyrosine positron emission tomography (ADC/FET) to be significantly more accurate than T1c MRI alone in the detection of tumor infiltration. This makes ADC/FET a suitable candidate to guide sup

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age ≥ 18 years * New clinical and radiological suspected diagnosis of IDH-wildtype glioblastoma or grade IV IDH-mutant astrocytoma * Visible FET PET uptake in the tumor as assessed by the nuclear physician * Indication for a surgical resection and adjuvant treatment according to the neuro oncology multidisciplinary meeting * Eligible for a supramarginal resection according to two neurosurgeons in consensus * Karnofsky Performance Score (KPS) ≥ 70. Exclusion Criteria: * Previous brain surgery or cranial radiotherapy * No significant other brain pathology, in the opinion of the PI or designee, such as multiple sclerosis, neurodegenerative disease, stroke * Tumor located infratentorially or in the spinal cord * Lack of adequate social or family support needed for adherence to the further postoperative therapeutic regimen * Pregnancy
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What it tests

  • Multimodal image-guided resection
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Where

1 site
Amsterdam UMC location VUmc
Amsterdam, Netherlands
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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