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โ† Trials
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PDMC Implementation Trial in Kenya

RecruitingPhase 4Ages any - 9 YearsAllLiverpool School of Tropical Medicine
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In plain words

What the trial is, and whether it could suit you

The goal of this implementation trial is to evaluate at least two alternative delivery strategies and adherence support for malaria chemoprevention with dihydroartemisinin-piperaquine in the post-discharge management of children hospitalised with severe anaemia or severe malaria to optimise adherence in Kenya. The actual interventions to be evaluated have been co-designed with national stakeholders during an initial formative research stage.

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: CLUSTERS * Health facilities with blood transfusion services offering in-patient care for children with severe anaemia and severe malaria. * \>=40 children per year admitted with severe anaemia or severe malaria * Agreement to participate by facility management * Located in areas with moderate to high malaria transmission INDIVIDUAL PARTICIPANTS * Aged \<10 years of both sexes * Hospitalised with severe anaemia or severe malaria: Initially hospitalised with haemoglobin \<5.0 g/dl or PCV \<15%, or requirement for blood transfusion for other clinical reasons on or during admission to the hospital, or severe malaria, defined as a requirement for parenteral artesunate in the opinion of the treating clinician and/or the presence of microscopy or RDT confirmed Plasmodium infection Exclusion Criteria: CLUSTERS \- Health facilities without subservient lower-level health facilities INDIVIDUAL PARTICIPANTS * Recognised specific other causes of severe anaemia (i.e., trauma, haematological malignancy, known bleeding disorders, such as haemophilia) * Sickle cell anaemia/sickle cell disease * Body weight \<5 kg * HIV infection and cotrimoxazole prophylaxis are not exclusion criteria.
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What it tests

  • SMS reminders; adherence support strategy a
  • Community Health Promoters (CHP) home visits; adherence support strategy b
  • No reminders; adherence support strategy c
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Where

1 site
Kemri, Cghr
Kisumu, Kenya
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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