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Exploring How Viral Infections Affect People With Chronic Lung Disease

Recruitingn/aAges 18 Years - anyAllImperial College London
NCT06625944 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Many people with chronic lung disease have disease flare-ups. It was previously believed that these were mainly caused by bacteria but recent evidence suggests that viruses could be an important trigger. This study will recruit volunteers with chronic lung disease and take samples both when well (at baseline) and during flare-ups (exacerbations) to better understand the role of viruses in triggering exacerbations and also how the immune response is affected. The researchers will follow the volunteers\' progress for up to two years. Whenever they get unwell they will take some samples (nose swabs, finger prick testing, phlegm sample) and post them to the researchers. Then, they will come in for a visit for more samples (blood tests, further swabs) and a review.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adults with a physician confirmed diagnosis of chronic airway disease (e.g. COPD and bronchiectasis) according to established diagnostic criteria. AND \- Prior history of exacerbation within last year (defined as requiring antibiotic and/or corticosteroids). Exclusion Criteria: * Inability to complete daily symptom diaries and/or attend for clinical assessments. * Exacerbation within 4 weeks of study recruitment and/or clinical instability at the time of recruitment. * Pregnancy.
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What it tests

  • Not listed
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Where

1 site
Royal Brompton Hospital
London, United Kingdom
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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