🌐 EnglishEN

AI Cure is a research tool showing open data. Not medical advice. Discuss with your doctor. Terms

← Trials
🧪

Transduction of Sympathetic Neural Activity in Human Obesity Without Hypertension

Recruitingn/aAges 18 Years - 79 YearsAllUniversity of Kansas Medical Center
NCT06626113 on ClinicalTrials.gov ↗
💬

In plain words

What the trial is, and whether it could suit you

In addition to chronically elevated MSNA, there is a growing recognition that hypertension in states of insulin resistance and obesity may also be attributed to an increased vascular sensitivity to MSNA (1, 2, 13, 36-38). To study this phenomenon, we quantify vascular sensitivity to MSNA using an innovative, moment-to-moment assessment of the blood pressure response following individual bursts of muscle sympathetic nerve activity (MSNA), (10, 11, 34, 37). This approach is termed 'sympathetic-vascular transduction (SVT).' We will examine the hypothesis that SVT is exaggerated in obesity and insulin resistance and is attenuated by suppression of oxidative stress. Oxidative stress is the overabundance of reactive oxygen species and is another hallmark of hypertension, obesity, and insulin resistance. Oxidative stress can be safely reduced via intravenous infusion of ascorbic acid (Vit C) (4

Sign in to get the eligibility rules as simple questions to take to your doctor.

Sign in
📋 Eligibility rules (as published)
Inclusion criteria: 1. Obese: BMI \>25 m/kg2 2. Elevated insulin resistance: HOMA-IR \> 2.5 (calculation based on fasting glucose and insulin concentrations in blood) 3. Middle-aged: 35-65 years 4. Participants must be willing and able to discontinue taking any vitamin C or E supplements or omega-3 fatty acids beginning 2 weeks prior. 5. Able and willing to provide written informed consent Exclusion criteria: 1. Currently taking a statin or antihypertension medication 2. Hyperlipidemia: Fasting triglycerides \< 250 mg/dL 3. Hypertension: \>130/80 mmHg 4. History of heart disease (e.g., myocardial infarction, stent) 5. History of vascular disease (e.g., bypass, stroke) 6. Individuals with narrow angle glaucoma \-
💊

What it tests

  • ascorbic acid
📍

Where

1 site
University of Kansas Medical Center
Kansas City, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
🛡️

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it — not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use · Privacy