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Prandial Metabolic Phenotyping in Sarcopenic Older Adults Comparing Plant Based and Whey Based Protein

RecruitingNAAges 50 Years - 95 YearsAllTexas A&M University
NCT06628349 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The researchers overall objective is to determine whether plant and animal protein based proteins affect the anabolic responses across aging populations differently due to specific changes in the essential amino acids (EAA) and non-essential amino acids (NEAA) kinetic responses. The researchers central hypothesis is that a high EAA to NEAA ratio in a protein meal is related to higher anabolic response to the meal. The researchers also hypothesize that the type of NEAA in a protein meal also affects the anabolic capacity of the meal. The researchers rationale is that finding the amino acid composition of a meal that will maximally induce protein anabolism will guide novel nutritional approaches to prevent and treat sarcopenia, thereby reducing both overall economic burden and improving individual patient outcomes.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age 50-95 years old * Diagnosis of Chronic Obstructive Pulmonary Disease (COPD); COPD group only * Stable body-weight (±5%) for the past 3 months * Ability to walk, sit down, and stand up (independently or with walking assistance device) * Willingness to lay supine in bed for up to 6 hours * Willingness and ability to comply with the protocol Exclusion Criteria: * Established diagnosis and active treatment of chronic disease: Insulin dependent diabetes mellitus, active malignancy, heart disease, kidney disease, liver disease, HIV/AIDS, Asthma (moderate to severe), Hep (A,B, or C) * History of untreated metabolic disease including hepatic or renal disorder * Presence of acute illness or metabolically unstable chronic illness * Hysterectomy * Active dependence of alcohol or drugs * Use of short course of oral corticosteroids within 4 weeks preceding study day * Current use of long-term oral corticosteroids * Use of protein or amino acids containing nutritional supplements within 5 days of the first study day * Presence of fever within the last 3 days * Planned elective surgery requiring 2 or more days of hospitalization during the entire study * (Possible) pregnancy * Failure to give informed consent or Investigator's uncertainty about the willingness or ability of the subject * Already enrolled in another clinical trial * Any condition according to the PI or nurse that was found during the screening visit, that would interfere with the study or safety of the patient * Known allergy to any of the components of the feeding (soy, pea, or whey - dairy) * Established daily diet of vegetarian / vegan composition * \<23 MoCa score
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What it tests

  • Whey Protein Isolate 90%
  • Soy Protein Isolate (90% Protein)
  • Organic Pea Protein Isolate
  • Placebo (Water)
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Where

1 site
Texas A&M University - CTRAL
College Station, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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