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A Multimodal Study of the Relationship Between Exposure to Endocrine Disruptors and Occurrence of Hypospadias - HYPOLLUT

Recruitingn/aAges 1 Month - anyAllUniversity Hospital, Montpellier
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In plain words

What the trial is, and whether it could suit you

This study aims to demonstrate the impact of Endocrine-Disrupting Chemicals (EDCs) on the risk of hypospadias incidence. It is a multicenter comparative case-control study, involving two groups. The first group consists of biological mothers who have given birth to children with hypospadias (Case Group), while the second group consists of biological mothers who have given birth to children without any malformations (Control Group). Through an integrative approach that combines a direct toxicological study of numerous pollutants present during pregnancy, and a comprehensive exposome assessment using validated tools, this study can significantly enhance our understanding and prevention of this malformation.

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Non-specific Inclusion Criteria : * Parents of legal age having signed a free and informed consent for the participation of their child * Biological mother of a boy aged between 1 and 6 months * Biological mother with a minimum hair length of 18 cm * Biological mother who has signed a free and informed consent for her participation * Biological mother and child affiliated with or beneficiaries of a national health insurance plan * Biological mother who is fluent in written and spoken French Specific Inclusion Criteria for Case Group: \- The child has an isolated anterior or middle hypospadias, without any other complex variations of genital development (borderline penile size, unilateral or bilateral cryptorchidism, retractile testes), without malformation syndrome and without identified genetic etiology Specific Inclusion Criteria for Control Group: \- The child must not present any complex variations in genital development (hypospadias, borderline penis size, unilateral or bilateral cryptorchidism, retractile testes) Exclusion Criteria: * Child with another congenital anomaly or malformative syndrome * Child with an endocrine pathology * Biological mother or child under legal protection, guardianship, or curatorship * Biological mother or child in the exclusion period of a previous study * Biological mother or child included in another clinical study involving a drug Specific Exclusion Criteria for Case Group: Biological mother/child pairs if a genetic variant explaining hypospadias is found during genetic analysis.
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What it tests

  • Consultation visit (Visit 1)
  • Consultation visit (Visit 1)
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Where

1 site
CRMR DEVGEN CHU Lapeyronnie
Montpellier, France
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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